News from NYU Langone Health
8-Year-Old Wheelchair User Can Walk Again – Thanks To An Experimental Drug Made Just For Him. (New York Post)
The (7/10) An eight-year-old boy with HPDL deficiency, a rare genetic condition affecting CoQ10 production, has regained his ability to walk after treatment with 4-HB, a compound able to cross the blood-brain barrier, marking the first human use of this supplement for the condition; Michael E. Pacold, MD, PhD, assistant professor, Department of Radiation Oncology, said, “ is safe. It’s reasonably effective at treating symptoms outside of the brain, but almost completely ineffective at treating symptoms within the brain, because it doesn’t get through the blood-brain barrier,” and is now working on a larger study following this promising case.
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Compound In Common Over-The-Counter Supplement Gives Little Boy, 8, The Ability To Walk Again. (Daily Mail (UK))
(7/10) Physicians at NYU Langone Health have successfully treated an eight-year-old boy with HPDL deficiency using a precursor to CoQ10 called 4-HB, which can cross the blood-brain barrier, allowing him to regain mobility and engage in physical activities like hiking and sports; Michael E. Pacold, MD, PhD, assistant professor, Department of Radiation Oncology, described the boy’s progress as “extremely well,” noting his ability to run and participate in various activities, despite the treatment not fully reversing symptoms, saying, “ is safe. It’s reasonably effective at treating symptoms outside of the brain, but almost completely ineffective at treating symptoms within the brain, because it doesn’t get through the blood-brain barrier.”
Also reporting are (7/10) and (7/10).
Yankees’ Mark Leiter Jr. Battled Through Left Leg Fracture. (New York Post)
The (7/10) “Lauren E. Borowski, MD, assistant professor, Department of Orthopedic Surgery, Sports Medicine Center, joins Brandon London for the weekly ‘Injury Report’ segment to discuss Yankees relief pitcher Mark Leiter Jr. pitching through a stress fracture in his left leg for nearly two weeks before being placed on the 15-day injured list.”
Five NY Research Centers Banding Together To Advance Cellular Therapy. (WGRZ-TV Buffalo (NY))
Buffalo, NY (7/10) NYU Langone Health is part of the newly formed Empire State Cellular Therapy Consortium, alongside Roswell Park Comprehensive Cancer Center, the University of Rochester’s Wilmot Cancer Institute, Mount Sinai’s Icahn School of Medicine, and Weill Cornell Medicine, created to advance cell and gene therapy; the consortium benefits from Roswell Park’s GMP Engineering and Cell Manufacturing Facility, with trials anticipated to commence within two years, aiming to provide early access to innovative treatments and expand access to FDA-approved cell therapies, as stated by Dr. Marco Davila, the Consortium’s inaugural chair, who described the partnership as a means to “bring new and better options to patients.”
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Woman Takes 10x Dose Of Turmeric, Gets Hospitalized For Liver Damage. (Ars Technica)
(7/10) A 57-year-old woman experienced severe liver damage after taking daily megadoses of turmeric, influenced by social media recommendations, and was treated at NYU Langone Health, where her hepatologist, Nikolaos Pyrsopoulos, MD, MBA, PhD, clinical professor, Department of Medicine, Division of Gastroenterology and Hepatology, Transplant Institute, said she was “one step before full liver damage, liver failure, requiring liver transplant”; her intake of 2,250 mg per day far exceeded the World Health Organization’s recommended dose, leading to symptoms such as stomach pain, nausea, fatigue, and dark urine, with blood tests revealing liver enzyme levels 60 times higher than normal, highlighting a rise in liver injuries linked to large doses of turmeric supplements.
The No. 1 Lunch Food Cardiologists Avoid For Heart Health. (TODAY)
(7/10) Cardiologists advise against consuming hamburgers and fries for lunch due to their contribution to atherosclerosis, cholesterol, diabetes, obesity, and high blood pressure, with Sean P. Heffron, MD, assistant professor, Department of Medicine, the Leon H. Charney Division of Cardiology, stating that this combination is “the poster lunch for atherosclerosis,” and Nieca Goldberg, MD, clinical associate professor, Department of Medicine, the Leon H. Charney Division of Cardiology, adding that it is “the absolute worst.”
Parents Crashing Honeymoons Becomes Bizarre New Travel Trend For Modern Newlyweds. (Fox News)
(7/9) A recent trend sees honeymooners bringing parents along on their trips, with social media users sharing stories of in-laws joining. Thea Gallagher, PsyD, clinical associate professor, Department of Psychiatry, described this as an “interesting concept,” suggesting it depends on the couple’s relationship with their parents and mutual agreement, advising against it if it prevents alone time but acknowledged it could be enjoyable if the couple loves their family.
How Stress And Ulcerative Colitis Are Linked And 6 Ways To Cope. (Everyday Health)
(7/10) Stress can exacerbate symptoms of ulcerative colitis (UC), an inflammatory bowel disease, according to Jordan E. Axelrad, MD, MPH, associate professor, Department of Medicine, Division of Gastroenterology and Hepatology, Inflammatory Bowel Disease Center, who said, “My patients always tell me that their symptoms feel worse when they’re stressed.” Treatment typically involves medications, but stress management techniques like yoga, deep breathing, hypnotherapy, improved sleep, exercise, and cognitive behavioral therapy can also alleviate discomfort and improve quality of life for UC patients.
Premenstrual Disorders Linked To Higher Risk For Heart Disease, Study Finds. (NBC News)
(7/11) New research analyzing data from over 3 million Swedish women over 20 years found an 11% increased risk of cardiovascular disease in those diagnosed with premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD), with a 24% increased risk for those diagnosed before age 25; Nieca Goldberg, MD, clinical associate professor, Department of Medicine, Joan H. Tisch Center for Women’s Health, explained that these disorders may indicate underlying physiological conditions like inflammation, which could lead to plaque buildup in arteries, and Priya Jaisinghani, MD, clinical assistant professor, Department of Medicine, the Holman Division of Endocrinology, Diabetes, & Metabolism, emphasized the need to focus on women’s risk factors for heart disease, including reproductive, hormonal, and metabolic conditions.
Here’s What Doctors Want You To Know ѵ Progesterone, The Other Hormone Causing Your Menopause Symptoms. (Oprah Daily)
(7/10) Progesterone, often overshadowed by estrogen in discussions of hormones and menopause, plays a crucial role in regulating the menstrual cycle, supporting pregnancy, and influencing mood, sleep, and bone strength; Margaret Nachtigall, MD, clinical associate professor, Department of Obstetrics and Gynecology, said, “In some people, progesterone can improve mood and cognition, and in others, it has the opposite effect,” highlighting the hormone’s complexity.
Psychologist Issues Warning As People Reveal Experiences With ‘Ozempic Sex’. (Unilad (UK))
(7/10) Concerns about the impact of Ozempic on sex drive have surfaced, with some users reporting decreased libido, while others experience increased sexual interest, according to Rachel L. Goldman, PhD, clinical assistant professor, Department of Psychiatry, who said that lifestyle changes after weight loss, similar to those seen post-bariatric surgery, can affect relationships; Goldman also explained that GLP-1 drugs target the brain’s reward center, potentially altering sex drive, and noted that these changes can lead to relationship challenges if partners do not adapt together.
News from NYU Langone Health—Long Island
NYU Langone Expands Healthcare In Suffolk County. (Long Island (NY) Business News)
(7/10) NYU Langone Health is expanding healthcare services in Middle Island and Patchogue, including primary care, cardiology, and surgeries, with Andrew Rubin, senior vice president, clinical affairs and ambulatory care, stating, “A key part of our mission is to bring world-class care to where our patients live and work.” The new NYU Langone Medical Associates – Middle Island facility, at 1299 Middle Country Road, features 13 exam rooms and two stress echocardiogram rooms, while NYU Langone Suffolk Plastic Surgery Associates – Patchogue, now part of the health system, is led by Nabil Kiridly, MD, clinical assistant professor, Department of Surgery, and chief, Plastic Surgery Service—Long Island.
Also reporting is (7/10).
Are Your Migraines Worse This Summer? These Factors Might Be Why, A Neurologist Explains. (CBS News)
(7/10) Shae Datta, MD, clinical assistant professor, Department of Neurology, Concussion Center—Long Island, explained to CBS News that many migraine sufferers experience increased headaches during the summer due to factors like weather changes and transitions between warm sun and air-conditioned environments, while the American Migraine Association advises staying hydrated, blocking out the sun, resting adequately, avoiding fragrances, and properly storing medications to mitigate migraine triggers during this season.
Also reporting is (7/10).
