News from NYU Langone Health
Tarlatamab Plus Anti–PD-L1 Therapy As Frontline Maintenance Shows Unprecedented OS In ES-SCLC. (OncLive)
(9/15) Extended follow-up findings from the phase 1b DeLLphi-303 trial presented at the IASLC 2025 World Conference on Lung Cancer revealed that adding tarlatamab-dlle to anti–PD-L1 therapy as frontline maintenance after chemoimmunotherapy achieved unprecedented overall survival and long-term tolerability in patients with extensive-stage small cell lung cancer, with a median overall survival of 25.3 months and a manageable toxicity profile; Sally Lau, MD, assistant professor, Department of Medicine, and a thoracic medical oncologist at NYU Langone’s Perlmutter Cancer Center, said, “Tarlatamab has been a major breakthrough for patients with ES-SCLC, who have had limited options for the past 30 years, and these data are impressive as a potential first-line maintenance treatment as well.”
Menopause Advice From Experts Who’ve Been There. (Health Central)
(9/15) Gynecologists provided insights on menopause management, emphasizing the importance of addressing symptoms such as hot flashes and mental health changes; Samantha M. Dunham, MD, clinical associate professor, Department of Obstetrics and Gynecology, Center for Midlife Health and Menopause, underscored the value of open communication with healthcare providers, saying, “This is a natural transition that’s going to happen to everyone,” while noting that many find happiness postmenopause due to the absence of painful periods and fear of pregnancy.
Menopause Symptoms And How To Treat Them. (Health Central)
(9/15) Menopause symptoms, which can include hot flashes, night sweats, and vaginal dryness, affect many women, with treatments varying from hormonal and non-hormonal options to complementary therapies, according to Samantha M. Dunham, MD, clinical associate professor, Department of Obstetrics and Gynecology, Center for Midlife Health and Menopause, who said, “Treatment depends on where someone is in their menopause transition.”
Heart Attacks In Younger Women More Often Not An Issue Of Atherosclerosis. (MedPage Today)
(9/15) A study led by Rajiv Gulati, MD, PhD, from Mayo Clinic, reveals that non-atherosclerotic causes of myocardial infarction (MI) are more prevalent in women under 65, with Harmony R. Reynolds, MD, the Joel E. and Joan L. Smilow Professor of Cardiology, Department of Medicine, the Leon H. Charney Division of Cardiology, saying in an editorial, “This is a source of uncertainty in the incidence estimates not only for MINOCA-U, but also for coronary artery spasm and myopericarditis,” adding, “Despite these caveats, the data on MI subtype incidence ... represent a major advance in our understanding of MI epidemiology in the young.”
Q&A: GLP-1 Drugs May Benefit CKD, Transplant Patients With Type 2 Diabetes. (Healio)
(9/15) A national cohort study found GLP-1 receptor agonist use in adults with type 2 diabetes on dialysis is associated with a 23% lower mortality risk and a 66% higher likelihood of kidney transplant wait-listing, with insights provided by Babak J. Orandi, MD, PhD, associate professor, Department of Surgery, Division of Transplant Surgery, and Department of Medicine, who concluded, “It would be helpful to understand the different beneficial mechanisms by which these medications are working.”
News from NYU Langone Hospital—Long Island
This Staple Could Lower Your Risk Of Dying From Dementia. (Parade Magazine)
(9/15) A recent study from May 2024 indicates that incorporating olive oil into one’s diet could reduce the risk of dementia-related mortality by 28%, with Shae Datta, MD, clinical assistant professor, Department of Neurology, NYU Langone Hospital—Long Island, explaining that consuming more than seven grams of olive oil daily, especially within a diet rich in fruits, vegetables, whole grains, nuts, and legumes, is associated with this reduced risk.
